Manuel Tetschke

PhD Student in the MathOpt research group
at the Faculty of Mathematics
at the Otto von Guericke University Magdeburg

Address

Universitätsplatz 2, 02-221a
39106 Magdeburg, Germany

phone: +49 391 67 51449
fax: +49 391 67 41171

Short CV

A long version is available on request.

Education

July 2015
– present:
Otto von Guericke University
PhD student and research assistant
Oct. 2011
– July 2014:
Otto von Guericke University (Magdeburg)
Master of Science in Mathematics, specialized in Optimal Control
Apr. 2009
– Dec. 2012:
Otto von Guericke University (Magdeburg)
Bachelor of Science in Computermathematics
Oct. 2007
– March 2009:
Martin-Luther-University (Halle)
Teacher training (mathematics and computer science)

Experience

March 2014
– June 2015:
IBM Services Center, Magdeburg, Germany
Application Development and project lead
April 2013
– Jan. 2014:
Volkswagen AG, Wolfsburg, Germany
Master thesis and internship: Non-linear model-predictive control applied to the example of a cooling-cycle of a car

Research interests

  • Global Optimal Control
  • Modelling of Erythropoiesis
  • Nonlinear Mixed-Integer Dynamic Optimization
  • Nonlinear Model-Predictive Control
  • Applications in medicine (blood diseases)
2022
article
Sager, S., Tetschke, M., Zeile, C.
A numerical study of transformed mixed-integer optimal control problems
Preprint
@article{Sager2022,
    author = {Sager, Sebastian and Tetschke, Manuel and Zeile, Clemens},
    title = {A numerical study of transformed mixed-integer optimal control problems},
    journal = {Preprint},
    year = {2022},
    note = {submitted},
    url = {https://optimization-online.org/2020/03/7698/}
}
2020
article
Lilienthal, P., Tetschke, M., Schalk, E., Fischer, T., Sager, S.
Optimized and Personalized Phlebotomy Schedules for Patients suffering from Polycythemia Vera
Frontiers in Physiology
@article{Lilienthal2020,
    author = {Lilienthal, P. and Tetschke, M. and Schalk, E. and Fischer, T. and Sager, S.},
    title = {Optimized and Personalized Phlebotomy Schedules for Patients suffering from Polycythemia Vera},
    journal = {Frontiers in Physiology},
    publisher = {Frontiers},
    year = {2020},
    volume = {11},
    pages = {328},
    url = {http://journal.frontiersin.org/article/10.3389/fphys.2020.00328}
}
2018
article
Tetschke, M., Lilienthal, P., Pottgiesser, T., Fischer, T., Schalk, E., Sager, S.
Mathematical Modeling of RBC Count Dynamics after Blood Loss
Processes
@article{Tetschke2018,
    author = {Tetschke, M. and Lilienthal, P. and Pottgiesser, T. and Fischer, T. and Schalk, E. and Sager, S.},
    title = {Mathematical Modeling of {RBC} Count Dynamics after Blood Loss},
    journal = {Processes},
    year = {2018},
    volume = {6},
    number = {9},
    pages = {157--185},
    doi = {10.3390/pr6090157}
}
2014
mastersthesis
Tetschke, M.
Nichtlineare Modell–prädiktive Regelung am Beispiel eines PKW–K\ḧlkreislaufes
Otto-von-Guericke Universität Magdeburg
@mastersthesis{Tetschke2014,
    author = {Tetschke, M.},
    title = {{N}ichtlineare {M}odell--pr\"adiktive {R}egelung am {B}eispiel eines {PKW}--{K}\"uhlkreislaufes},
    school = {Otto-von-Guericke Universit\"at Magdeburg},
    year = {2014}
}
2013
inproceedings
Heil, P., Neubauer, H., Tetschke, M., Irvine, D. R. F.
A Probabilistic Model of Absolute Auditory Thresholds and Its Possible Physiological Basis
Basic Aspects of Hearing
Detection thresholds for auditory stimuli, specified in terms of their amplitude or level, depend on the stimulus temporal envelope and decrease with increasing stimulus duration. The neural mechanisms underlying these fundamental across-species observations are not fully understood. Here, we present a ``continuous look'' model, according to which the stimulus gives rise to stochastic neural detection events whose probability of occurrence is proportional to the 3rd power of the low-pass filtered, time-varying stimulus amplitude. Threshold is reached when a criterion number of events have occurred (probability summation). No long-term integration is required. We apply the model to an extensive set of thresholds measured in humans for tones of different envelopes and durations and find it to fit well. Subtle differences at long durations may be due to limited attention resources. We confirm the probabilistic nature of the detection events by analyses of simple reaction times and verify the exponent of 3 by validating model predictions for binaural thresholds from monaural thresholds. The exponent originates in the auditory periphery, possibly in the intrinsic Ca2+ cooperativity of the Ca2+ sensor involved in exocytosis from inner hair cells. It results in growth of the spike rate of auditory-nerve fibers (ANFs) with the 3rd power of the stimulus amplitude before saturating (Heil et al., J Neurosci 31:15424–15437, 2011), rather than with its square (i.e., with stimulus intensity), as is commonly assumed. Our work therefore suggests a link between detection thresholds and a key biochemical reaction in the receptor cells.
@inproceedings{10.1007/978-1-4614-1590-9_3,
    author = {Heil, Peter and Neubauer, Heinrich and Tetschke, Manuel and Irvine, Dexter R. F.},
    title = {A Probabilistic Model of Absolute Auditory Thresholds and Its Possible Physiological Basis},
    booktitle = {Basic Aspects of Hearing},
    publisher = {Springer New York},
    year = {2013},
    editor = {Moore, Brian C. J. and Patterson, Roy D. and Winter, Ian M. and Carlyon, Robert P. and Gockel, Hedwig E},
    pages = {21--29},
    address = {New York, NY}
}

Prof. Dr. rer.nat. habil. Sebastian Sager Head of MathOpt group
at the Institute of Mathematical Optimization
at the Faculty of Mathematics
at the Otto von Guericke University Magdeburg

Universitätsplatz 2, G02-224
39106 Magdeburg, Germany

: +49 391 67 58745
: +49 391 67 11171
:

Susanne Heß

Universitätsplatz 2, G02-206
39106 Magdeburg, Germany

: +49 391 67-58756
: +49 391 67-11171
:

Prof. Dr. rer.nat. habil. Sebastian Sager Head of MathOpt group
at the Institute of Mathematical Optimization
at the Faculty of Mathematics
at the Otto von Guericke University Magdeburg

Universitätsplatz 2, G02-224
39106 Magdeburg, Germany

: +49 391 67 58745
: +49 391 67 11171
:

Susanne Heß

Universitätsplatz 2, G02-206
39106 Magdeburg, Germany

: +49 391 67-58756
: +49 391 67-11171
: